Regular Article IMMUNOBIOLOGY IL-12 receptor b1 deficiency alters in vivo T follicular helper cell response in humans
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چکیده
• IL-12Rb1–deficient subjects displayed substantially less circulating memory Tfh and memory B cells than control subjects. • The IL-12–STAT4 axis is associated with the development and functions of Tfh cells in vivo in humans. Antibody responses represent a key immune protection mechanism. T follicular helper (Tfh) cells are the major CD4 T-cell subset that provides help to B cells to generate an
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